So thanks so much for joining us today. * Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. Fellowship - Jefferson Medical College of Thomas Jefferson University
The primary end-point was pathologic down staging to PT1 or below at surgery, and the study was aimed at achieving at least 45% at cystectomy. Dr. Shilpa has 3 jobs listed on their profile. As such, gifts of substantial value are generally prohibited. Have a great day. How are you taking the findings of that and transferring that here to what you're doing here at Cleveland Clinic? 9500 Euclid Avenue, Cleveland, Ohio 44195 |. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page. 2011, Fellowship - Jefferson Medical College of Thomas Jefferson University
Apple Podcasts | Google Podcasts | SoundCloud | Spotify | Blubrry | Stitcher. Shilpa has 4 jobs listed on their profile. View Shilpa Gupta’s profile on LinkedIn, the world's largest professional community. Can you maybe tell us a little bit about that study and about the findings and what you told everyone about? PA USA
Dale Shepard, MD, PhD: Yeah. Shilpa has 2 jobs listed on their profile. What was the key to the success in getting this trial to happen? DC USA
See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. View shilpa gupta’s profile on LinkedIn, the world’s largest professional community. We are collaborating with Dr. Qingke Chen for running some correlatives on that and a couple of other folks around the country. CORONAVIRUS: DELAYS FOR ROUTINE SURGERIES, VISITOR RESTRICTIONS + COVID-19 TESTING. Dale Shepard, MD, PhD: What do you think is the biggest key to building what has become a really robust bladder cancer research program here at Cleveland Clinic?
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Dr. Gupta is active in several professional organizations including the American Society of Clinical Oncology (ASCO), American Urologic Association (AUA), American Association of Cancer Research (AACR), Society of Urologic Oncology (SUO), Society of Immunotherapy for cancer (SITC), Bladder Cancer Advocacy Network (BCAN), Prostate Cancer Foundation (PCF) and the European society of Medical Oncology (ESMO). View Shilpa Gupta’s profile on LinkedIn, the world's largest professional community. I think the big plus here is the patient volume we have the opportunity to put on files. Subscribe to the podcast on iTunes, GooglePlay, Spotify, SoundCloud, or wherever you listen to podcasts. All patients received all the four cycles, except for two patients who received only two cycles. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. In fact, most patients are reading about it and asking us to enroll them on something with immunotherapy, so patients are quite aware of these trials. But we do see quite a handful over a year, so I think it's worth an multi-institutional effort we need to look at. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Shilpa has 2 jobs listed on their profile. All the urology colleagues, radiation oncology colleagues, Dr. Mian, who actually is leading another Department of Defense TTSA grant this year, and I'm the co-PI on that along with Dr. Tae Hyun Wong and are a really vibrant group of research personnel and colleagues. Dale Shepard, MD, PhD: How about patients? Shilpa has 1 job listed on their profile. Please join us again soon. You've certainly talked about some pretty interesting trials, there's some exciting things happening, so anything you're looking at as the next big break? As of 1/6/2021, Dr. Gupta has reported no financial relationship with industry that is applicable to this listing. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. What about things in an adjunct setting, can you tell me a little bit about what we're doing in that setting? Shilpa Gupta, MD: Yes, absolutely. Shilpa Gupta, MD: Yeah, I think that's a great question, and I would love to get involved with some efforts of sending out communication newsletters, or I think this Cancer Advances circulation should help also. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Shilpa has 1 job listed on their profile. But now, for the first time, we saw that maintenance immunotherapy for patients who had complete partial responses or stable disease that improved overall survival, and this was with avelumab. But we do. Our patients here know that in any case, even if they don't go on a trial, 12 weeks of chemotherapy is standard, and after that, within six to eight weeks, they get operated upon. Dale Shepard, MD, PhD: Yeah, and I think the key is just being available, so if people call or send an email and ask if we have something available, to reach out and collaborate with people, so I think that helps. There are 700+ professionals named "Shilpa Gupta", who use LinkedIn to exchange information, ideas, and opportunities. This concludes this episode of Cancer Advances. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Thanks for the opportunity. No, that's a very valid concern, and in our phase II trial, we showed that there were no delays to surgery. That's an excellent question, Dale. To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved. I'm your host, Dr. Dale Shepard, a medical oncologist here at Cleveland Clinic, overseeing our Taussig Phase I and Sarcoma Programs. Shilpa, can you tell me a little bit about your role here at Cleveland Clinic? See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. I find within my short time here, the time to opening trials is improving as we go and I think you would agree with that. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. 9500 Euclid Avenue, Cleveland, Ohio 44195 |. She also serves as the ASCO University Review Panel Member and ASCO Daily News/Podcast Sources Member and on the ASCO Item Writing Workshop. She's here today to discuss clinical trials in bladder cancer. Patients received four cycles of gemcitabine and cisplatin with nivolumab added on day eight of each cycle. Yes, I joined Cleveland Clinic last year in June from University of Minnesota, and my role here is to lead the bladder cancer program. See the complete profile on LinkedIn and discover SHILPA’S connections and jobs at similar companies. Shilpa Gupta has 2 jobs listed on their profile. SHILPA has 6 jobs listed on their profile. Thank you for listening. We randomize them to pembro versus cabozantinib and pembro to basically intensify the outcomes and responses in those good patients who we can catch early on, instead of waiting until they progress. Hematology-Oncology Washington,
See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Shilpa Gupta, MD: Yeah, I think the team here is really fantastic. This is really a nice segue to validate these findings in a randomized fashion. WI USA
Dale Shepard, MD, PhD: How are you taking the findings of that and transferring that here to what you're doing here at Cleveland Clinic? Shilpa Gupta, MD: But we do. That concern, I would say, is not a factor at all. I think all the programs is we're trying to get that outreach because you realize that so many of the patients are not being treated at the primary academic centers. Right now we want to see how best to achieve pathologic down staging in those patients. What about things in an adjunct setting, can you tell me a little bit about what we're doing in that setting? Dr. Gupta has been appointed to serve on the ASCO Annual Meeting Scientific Program and the SITC Anti-PD-1/PD-L1 Resistance Taskforce. Yes. Cleveland Clinic Cancer Center oncologist Shilpa Gupta, MD discusses promising findings in the treatment of advanced bladder cancer in this week's Cancer Advances podcast. Yeah, sure. View the profiles of professionals named "Shilpa Gupta" on LinkedIn. Based on this trial, we actually got the Department of Defense Idea Award for this year, looking at immune biomarkers, like resistance and response biomarkers to immunotherapy. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Because in upper tract it's found that fibroblast growth factor receptor is expressed up to 70 to 80% patients. Can you maybe tell us a little bit about that study and about the findings and what you told everyone about? Im Profil von Shilpa Gupta sind 3 Jobs angegeben. But I think as an institutional-wide effort, it would be good to have a disease-specific flyer go out to these. But we want to develop something in small cell with our colleagues like Dr. Omar Mian from rad-onc, who has interest in that as a basic scientist. In that trial, we are prospectively selecting based on the biomarker. Shilpa has 3 jobs listed on their profile. Subscribe:
There were no grade four or grade five events, no delayed or immediate immune-related adverse events, which affected timing of surgery. Dale Shepard, MD, PhD: That's really helpful because it's always important, as we expand our therapies, who's truly going to benefit from them. Shilpa has 3 jobs listed on their profile. Subscribe to the podcast on iTunes, GooglePlay, Spotify, SoundCloud, or wherever you listen to podcasts. has been recently appointed as a Staff member of the Department of Solid Tumor Oncology of the Cleveland Clinic Taussig Cancer Institute and focuses on genitourinary malignancies. Shilpa Gupta, M.D. Shilpa a 6 postes sur son profil. CT USA
View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Shilpa has 9 jobs listed on their profile. Yeah, absolutely. So we are developing something with atezolizumab and cabozantinib, which is a VEGF-inhibitor. Thanks for the opportunity. So these results were very promising, overall. We currently have that open at Cleveland Clinic. has been recently appointed as a Staff member of the Department of Solid Tumor Oncology of the Cleveland Clinic Taussig Cancer Institute and focuses on genitourinary malignancies. Yes, absolutely. Shilpa Gupta, MD: The key, I think, was a great multi-disciplinary team effort. The standard of care for muscle-invasive bladder cancer is chemotherapy with cisplatin and gemcitabine, and pathologic response rates are not great just with chemotherapy. What have you found, and how have you managed to offset their concerns? Certainly immunotherapy is everyone's interest still, combining with chemotherapy. 2001, Genitourinary Cancers: Bladder Cancer, prostate Cancer, Kidney Cancer, Testicular Cancer, (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. She completed Hematology-Oncology fellowship at Thomas Jefferson University followed by a Genitourinary Oncology Translational Research fellowship there in Dr. Marja Nevalainen’s laboratory. Shilpa Gupta, MD: Thanks, Dale. Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan. It's quite exciting. Shilpa has 8 jobs listed on their profile. You will find additional podcast episodes on our website, clevelandclinic.org/canceradvancespodcast. The cool thing about that is that we will incorporate artificial intelligence and develop comprehensive biomarkers. Dale Shepard, MD, PhD: How do you see this moving forward? View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. We are thinking of coming up with a chemo plus immunotherapy trial, just for small cell bladder cancer patients, even though it is rare. More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved.
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