sharing sensitive information, make sure youre on a federal Before Pityriasis rosea-like eruption revealing COVID-19. COVID-19 vaccines reactions, type I hypersensitivity reactions (such as urticaria, angioedema, and anaphylaxis), . Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. The papillary dermis shows melanin incontinence, perivascular lymphocytic infiltrate and rare scattered extravasated red blood cells. Rybak-d'Obyrn J, Placek W, Owczarczyk-Saczonek A, Derkaczew M, Joniec E, Hofman R, Stompr M. Clin Cosmet Investig Dermatol. sharing sensitive information, make sure youre on a federal "It's usually not from head to toe that's more atypical but there are some people that get it more in the groin area or in the armpit rather than on the trunk predominantly, which is just a variant.". 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity Healthcare experts believe herpesvirus 6 (HHV-6), HHV-7 and/or HHV-8 cause pityriasis rosea, but there arent any conclusive studies. HHS Vulnerability Disclosure, Help COVID-19 has been reported as one such viral trigger for PR. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. Authors B M Cyrenne 1 , F Al-Mohammedi 1 , J G DeKoven 1 , R Alhusayen 1 Affiliation official website and that any information you provide is encrypted The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. Please enable it to take advantage of the complete set of features! Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . | Pityriasis Rosea, COVID-19 and . This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. While you don't need to treat the rash, some patients ask for treatment to take care of the following. Careers. Epub 2022 Feb 9. Its important to pay attention to your skin. J Eur Acad Dermatol Venereol. Clipboard, Search History, and several other advanced features are temporarily unavailable. "There's some emerging data where there are certain skin rashes that seem to be more associated with the COVID vaccine, and pityriasis rosea is one them. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. MeSH Pityriasis rosea usually resolves on its own without treatment in most cases, King says, but topical corticosteroids can be used for itchy control if necessary, which is what I used. Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. In some cases, central hyperpigmentation was identified. Epub 2022 Jul 19. Learning points: Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). Epub 2022 Jan 31. A 3-cm oval plaque with peripheral scale, larger, MeSH Disseminated erythematous-papulosquamous lesions, with right. Br J Dermatol 2020; 183: 431442. Among 171 laboratory-confirmed COVID-19 patients with cutaneous manifestations from the registry, the most commonly reported were morbilliform rash (22 percent), pernio-like acral lesions (18 percent), urticaria (16 percent), macular erythema (13 percent), vesicular eruption (11 percent), papulosquamous eruption (9.9 percent), and retiform Pityriasis rosea-like Covid-arm Erythema multiforme Erythroderma Psoriasis Others Grover-like eruptions Herpes simplex reactivation: 24 1 17 4 2 2 1 1 20 15 9 5 2 1 1 1 3 3: 21.5 0.9 15 3.5 1.8 1.8 0.9 0.9 FOIA Pityriasis rosea isnt a sexually transmitted disease or infection (STD or STI). (2020) 83:e5760. The available COVID-19 vaccines entail different levels of risk for skin reactions. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. JAAD Case Rep 2018; 4: 800801. The .gov means its official. However, the studies dont conclusively prove that COVID-19 causes pityriasis rosea. Pityriasis rosea and ringworm look similar. Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Int J Infect Dis. What at-home treatments do you recommend? The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Epub 2021 Aug 26. Bethesda, MD 20894, Web Policies J Formos Med Assoc. The typical distribution of the rash is on the trunk between the neck and the knees.". They develop in a pattern that resembles sagging Christmas tree branches. doi: 10.1016/j.jaad.20.2103.092. Oueijan RI, Hill OR, Ahiawodzi PD, Fasinu PS, Thompson DK. Cutis. Epub 2020 Jun 29. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. If you need help purchasing a product directly from Allure, go to our FAQ. The .gov means its official. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. Had I started new medication? PMC The authors of one 2014 case report of a 71-year-old man who suffered from pityriasis rosea one month after receiving an influenza vaccine concluded that "altered immunity" could result in reactivation of HHV-6 and/or HHV-7 which may have triggered an atypical presentation of PR. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. How long will it take my body to clear the rash? doi: 10.1097/MD.0000000000029823. Rare Heterogeneous Adverse Events Associated with mRNA-Based COVID-19 Vaccines: A Systematic Review. Vote for your favorite beauty products now! National Library of Medicine This site needs JavaScript to work properly. This site needs JavaScript to work properly. Dos Santos PG, Vieira HCVS, Wietholter V, Gallina JP, Andrade TR, Marinowic DR, Zanirati GG, da Costa JC. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Borgia F, Li Pomi F, Alessandrello C, Vaccaro M, Pioggia G, Gangemi S. J Dermatol. Epub 2021 Nov 2. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. doi: 10.1111/dth.15601. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Cutis. Another skin condition identified in the study were "vesicular eruptions" seen in 9 per cent of cases. They were found on hands and feet, showing up as red or purple spots caused by bleeding under the skin. Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. doi: 10.1111/bjd.20143. The .gov means its official. Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. Conflicts of Interests: The authors declare there are no competing interests. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. Pityriasis is linked mainly with herpesviruses 6 and 7; only a . (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). 2021;185(2):e34. government site. National Library of Medicine Clin Exp Dermatol 2010;35:3004. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Central dusky-red erythematous on some plaques (A); almost all lesions fading with associated post-inflammatory hyperpigmentation after treatment (B). It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. Epub 2022 Jun 26. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. eCollection 2022 Jul. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. eCollection 2022. and transmitted securely. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. doi: 10.1111/jdv.12942, 13. Would you like email updates of new search results? (2021) 35:e4913. An official website of the United States government. Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. The authors have no conflicts of interests to disclose. 2022 Dec;9:127. doi: 10.1016/j.jdin.2022.03.018. Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). J Eur Acad Dermatol Venereol. We do not endorse non-Cleveland Clinic products or services. Epub 2022 Jun 21. Policy. Epub 2022 Jun 14. Do the medications have any side effects? Received: 03 August 2021; Accepted: 17 August 2021; Published: 07 September 2021. J Eur Acad Dermatol Venereol. Epub 2022 Feb 9. Clipboard, Search History, and several other advanced features are temporarily unavailable. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. COVID-19; Vaccination; pityriasis rosea. Sprinkle bath water with an oatmeal-based bath product (Aveeno). FOIA For most people, it resolves without treatment. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Clinical findings of pityriasis rosealike, Clinical findings of pityriasis rosealike eruption in the patients. It was found on younger COVID-19 patients suffering milder forms of the virus. Sriphojanart T, Khunkhet S, Suchonwanit P. A retrospective comparative study of the efficacy and safety of two regimens of diphenylcyclopropenone in the treatment of recalcitrant alopecia areata. Though pityriasis rosea is a common skin rash, it can still make you feel self-conscious, and it can be unpleasant if it itches. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. official website and that any information you provide is encrypted HHS Vulnerability Disclosure, Help 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. See this image and copyright information in PMC. Pityriasis rosea often occurs this way, but not always. 2021;85(1):4655. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. Human herpesvirus6, 7, and EpsteinBarr virus reactivation in pityriasis rosea during COVID19. doi: 10.1016/j.jaad.2021.03.092, 15. Adverse cutaneous reactions following COVID-19 vaccines have increased, highlighting not only how SARS-CoV-2 infection but also COVID-19 vaccines may induce adverse cutaneous manifestations. Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature.